Adrenocortical Carcinoma: Review of the Pathologic Features, Production of Adrenal Steroids, and Molecular Pathogenesis

Yasuhiro Nakamura, Yuto Yamazaki, Saulo J. Felizola, Kazue Ise, Ryo Morimoto, Fumitoshi Satoh, Yoichi Arai, Hironobu Sasano

研究成果: Review article査読

20 被引用数 (Scopus)

抄録

Adrenocortical carcinoma (ACC) is a malignant neoplasm often associated with an aggressive biological behavior. The histologic differentiation between ACC and adrenocortical adenoma (ACA) is largely determined by employing the Weiss criteria, although this classification may not apply to all the cases. Additionally, various genomic features of ACC could be an auxiliary mode to establish the diagnosis of ACC. Most ACC cases are hormonally functional, and immunohistochemical analysis of steroidogenic enzymes has provided pivotal information as to the analysis of intratumoral production of corticosteroids. This article summarizes the current status of the histopathological diagnosis, molecular pathogenesis, and hormonal features of ACC.

本文言語English
ページ(範囲)399-410
ページ数12
ジャーナルEndocrinology and Metabolism Clinics of North America
44
2
DOI
出版ステータスPublished - 2015 6 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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