Adrenarche is associated with decreased 3β-hydroxysteroid dehydrogenase expression in the adrenal reticularis

J. S. Gell, B. Atkins, L. Margraf, J. I. Mason, H. Sasano, W. E. Rainey, B. R. Carr

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The increased production of adrenal dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) which occurs during the prepubertal period is known as adrenarche. One hypothesis for adrenarche is that alterations in intra- adrenal expression of steroidogenic enzymes within the inner reticularis zone leads to the increased production of 19-carbon steroids. We tested the hypothesis that at the time of adrenarche there is decreased expression of 3βHSD in the reticularis. Immunohistochemical localization of 3βHSD was performed and staining intensities compared between adrenal glands from children ages 4 months to 7 years (N=11) and ages 8 to 11 years (N=6). No difference was observed between the levels of staining in the glomerulosa and fasciculata from either age group. However, the reticularis from the older children exhibited diminished 3βHSD immunoreactivity. These findings suggest that as children mature there is a decreased level of 3βHSD in the adrenal reticularis which may contribute to the increased production of DHEA and DHEAS seen during adrenarche.

本文言語English
ページ(範囲)723-728
ページ数6
ジャーナルEndocrine Research
22
4
DOI
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 内分泌学

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