ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1

Yuichi Hirata, Naoki Kimura, Koh Sato, Yoshiyuki Ohsugi, Shin Takasawa, Hiroshi Okamoto, Jun Ishikawa, Tsuneyasu Kaisho, Katsuhiko Ishihara, Toshio Hirano

研究成果: Article査読

144 被引用数 (Scopus)

抄録

Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST-1 might possess ADP ribosyl cyclase activity. Here, we report the establishment of a stable transformant CHO cell line which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase cADPR hydrolase activities.

本文言語English
ページ(範囲)244-248
ページ数5
ジャーナルFEBS Letters
356
2-3
DOI
出版ステータスPublished - 1994 12 19

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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