Adiponectin suppresses tumorigenesis in ApcMin/+ mice

Kensuke Otani, Joji Kitayama, Koji Yasuda, Yasunori Nio, Masato Iwabu, Shinichi Okudaira, Junken Aoki, Toshimasa Yamauchi, Takashi Kadowaki, Hirokazu Nagawa

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Recent reports have shown that adiponectin has a suppressive effect on various types of malignancy. In order to clarify the role of adiponectin in colorectal carcinogenesis, we examined the effect of exogenous administration of adiponectin on intestinal polyp formation in C57BL/6 J-ApcMin/+ mice, which possess a point mutation in the Apc gene. And we found that adiponectin treatment significantly decreased the number of adenomatous polyps, especially polyps larger than 2 mm in diameter, in the small intestine. Two major receptors for adiponectin, AdipoR1 and AdipoR2, were expressed in adenomatous polyps, and their expression levels were not altered by adiponectin injection. In conclusion, adiponectin suppresses the growth of intestinal adenomas in the ApcMin/+ mice. Increasing the adiponectin level may be a new strategy for the prevention of colorectal cancer at an early step of carcinogenesis.

本文言語English
ページ(範囲)177-182
ページ数6
ジャーナルCancer Letters
288
2
DOI
出版ステータスPublished - 2010 2月 28

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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