Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing

Gowri Nayak, Kevin X. Zhang, Shruti Vemaraju, Yoshinobu Odaka, Ethan D. Buhr, Amanda Holt-Jones, Stace Kernodle, April N. Smith, Brian A. Upton, Shane D'Souza, Jesse J. Zhan, Nicolás Diaz, Minh Thanh Nguyen, Rajib Mukherjee, Shannon A. Gordon, Gang Wu, Robert Schmidt, Xue Mei, Nathan T. Petts, Matthew BatieSujata Rao, John B. Hogenesch, Takahisa Nakamura, Alison Sweeney, Randy J. Seeley, Russell N. Van Gelder, Joan Sanchez-Gurmaches, Richard A. Lang

研究成果: Article査読

27 被引用数 (Scopus)

抄録

White adipocytes activate the lipolysis pathway to produce the free fatty acids that are used as heating fuel by brown adipose tissue. Nayak et al. show that Opsin 3 is required for blue-light-enhanced activation of the lipolysis pathway. This explains the low body temperature of Opn3 mutant mice.

本文言語English
ページ(範囲)672-686.e8
ジャーナルCell Reports
30
3
DOI
出版ステータスPublished - 2020 1 21

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル