抄録
Two galectins isolated from the skin mucus of conger eel (Conger myriaster), named congerins I and II, are dimers composed of two identical subunits of 136 and 135 amino acid residues, respectively. They belong to the proto-type galectins and showed 48% sequence identity and different thermal stabilities and different sugar binding. The molecular evolutionary analyses and X-ray crystallography analyses of congerins I and II reveal that they have evolved in an accelerating and adaptive manner to the emergence of a new structure including domain-swapping manner and a unique new ligand-binding site. In this review, we summarize and discuss the structure-properties/function relationships and the molecular evolution of fish galectins.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 177-187 |
| ページ数 | 11 |
| ジャーナル | Trends in Glycoscience and Glycotechnology |
| 巻 | 14 |
| 号 | 77 |
| DOI | |
| 出版ステータス | Published - 2002 5月 |
ASJC Scopus subject areas
- 生化学
- 有機化学