Active control of bubble liposome through artificial capillary by using matrix array transducer

Ren Koda, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama

研究成果: Conference contribution

抄録

We have ever reported our attempts to control microbubbles (MBs) using the primary and secondary acoustic force for active control in artificial blood vessels. Recently, we have demonstrated active path selection of MBs by using a matrix array transducer to produce multiple focal points. On the other hand, bubble liposomes (BLs) have an advantage in easily modifying targeting ligand. However, considering that BLs are several hundred nanometers in diameter, there were some difficulties in controllability of bubbles in blood flow under ultrasound exposure, since acoustic forces are less affected to these small bubbles. In this study, we used the liposomes (BLs) entrapping perfluoropropane gas with the average diameter of 500 nm and applied it to control the behavior in an artificial blood vessel. First, we observed aggregates formation of BLs in static water by secondary acoustic force. Next, we investigated the BLs control in multi-bifurcated flow by using a matrix array transducer. As a result, the streaming of BLs was viscously propelled to a desired path. BLs are much tied each other because of surface interaction of the lipid membrane and then caused a resistance to flow compare to MBs.

本文言語English
ホスト出版物のタイトル2013 IEEE International Ultrasonics Symposium, IUS 2013
ページ2099-2102
ページ数4
DOI
出版ステータスPublished - 2013
イベント2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
継続期間: 2013 7 212013 7 25

出版物シリーズ

名前IEEE International Ultrasonics Symposium, IUS
ISSN(印刷版)1948-5719
ISSN(電子版)1948-5727

Other

Other2013 IEEE International Ultrasonics Symposium, IUS 2013
国/地域Czech Republic
CityPrague
Period13/7/2113/7/25

ASJC Scopus subject areas

  • 音響学および超音波学

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