Active control by external factors of DNA recognition behavior of α-peptide ribonucleic acids containing basic amino acid residues

Takehiko Wada, Nobuya Sawa, Hirofumi Sato, Mayuko Kikkawa, Keiko Onodera, Seiji Sakamoto, Yoshihisa Inoue

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA-Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second- generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between, the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.

本文言語English
ページ(範囲)112-113
ページ数2
ジャーナルChemistry Letters
39
2
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • 化学 (全般)

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