Activation of the hypothalamic feeding centre upon visual prey detection

Akira Muto, Pradeep Lal, Deepak Ailani, Gembu Abe, Mari Itoh, Koichi Kawakami

    研究成果: Article査読

    51 被引用数 (Scopus)

    抄録

    The visual system plays a major role in food/prey recognition in diurnal animals, and food intake is regulated by the hypothalamus. However, whether and how visual information about prey is conveyed to the hypothalamic feeding centre is largely unknown. Here we perform real-time imaging of neuronal activity in freely behaving or constrained zebrafish larvae and demonstrate that prey or prey-like visual stimuli activate the hypothalamic feeding centre. Furthermore, we identify prey detector neurons in the pretectal area that project to the hypothalamic feeding centre. Ablation of the pretectum completely abolishes prey capture behaviour and neurotoxin expression in the hypothalamic area also reduces feeding. Taken together, these results suggest that the pretecto-hypothalamic pathway plays a crucial role in conveying visual information to the feeding centre. Thus, this pathway possibly converts visual food detection into feeding motivation in zebrafish.

    本文言語English
    論文番号15029
    ジャーナルNature communications
    8
    DOI
    出版ステータスPublished - 2017

    ASJC Scopus subject areas

    • 化学 (全般)
    • 生化学、遺伝学、分子生物学(全般)
    • 物理学および天文学(全般)

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