Activation of central GABAA receptors suppresses the alteration of plasma catecholamine levels induced by neostigmine or histamine in rats

Katsunori Nonogaki, Kotomi Mizuno, Nobuo Sakamoto, Akihisa Iguchi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We investigated the effects of intraventricular injection of muscimol, the GABAA receptor agonist, on the alteration of plasma epinephrine (E) and norepinephrine (NE) levels induced by neostigmine or histamine in anesthetized rats. Injection of neostigmine (10 nmol) into the third cerebral ventricle increased plasma levels of E more than NE, while histamine (500 nmol) increased plasma levels of NE more than E. Concomitant injection of muscimol (2.5 nmol) with neostigmine or histamine significantly suppressed the alteration of E and NE levels induced by neostigmine or histamine. These findings suggest that activation of central cholinergic neuron stimulates the adrenal medullary response more than the sympathetic nervous system, while activation of central histaminergic neuron stimulates the sympathetic nervous system more than the adrenal medullary response in anesthetized rats. Activation of GABAA receptors in the CNS suppresses these effects.

本文言語English
ページ(範囲)PL409-PL413
ジャーナルLife Sciences
55
21
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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