Actin-related proteins localized in the nucleus: From discovery to novel roles in nuclear organization

Yukako Oma, Masahiko Harata

研究成果: Review article査読

45 被引用数 (Scopus)

抄録

The actin family consists of conventional actin and actin-related proteins (ARPs), and the members show moderate similarity and share the same basal structure. Following the finding of various ARPs in the cytoplasm in the 1990s, multiple subfamilies that are localized predominantly in the nucleus were identified. Consistent with these cytological observations, subsequent biochemical analyses revealed the involvement of the nuclear ARPs in ATP-dependent chromatin-remodeling and histone acetyltransferase complexes. In addition to their contribution to chromatin remodeling, recent studies have shown that nuclear ARPs have roles in the organization of the nucleus that are independent of the activity of the above-mentioned complexes. Therefore, nuclear ARPs are recognized as novel key regulators of genome function, and affect not only the remodeling of chromatin but also the spatial arrangement and dynamics of chromatin within the nucleus.

本文言語English
ページ(範囲)38-46
ページ数9
ジャーナルNucleus
2
1
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 細胞生物学

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