Acetazolamide specifically inhibits lingual trigeminal nerve responses to carbon dioxide

Michio Komai, Bruce P. Bryant

研究成果: Article査読

64 被引用数 (Scopus)


The goal of this study was to examine the role of the enzyme, carbonic anhydrase, in oral trigeminal chemoreception with particular regard to the reception of CO2. Using both single and multiunit recordings of trigeminal neurons in the lingual nerve of rat, we measured responses to cool (24°C), noxiously hot (55°C) and cold (8°C) H2O, NH4Cl and supersaturated solutions of CO2 (24°C and 33°C). The importance of peripheral carbonic anhydrase was tested by inhibiting enzyme activity with acetazolamide (15 mg/kg b.w.). Single unit responses to CO2 and HCl suggest that neural sensitivity to CO2 is not simply a function of extraepithelial pH. Responses to CO2 were significantly inhibited by acetazolamide while the responses to thermal stimuli and NH4Cl were not. The results support a role for carbonic anhydrase in trigeminal responses to CO2. Furthermore, the results suggest that intraepithelial acidification mediated by carbonic anhydrase may be the basis for sensitivity to CO2.

ジャーナルBrain research
出版ステータスPublished - 1993 5 28

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学


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