Accuracy of catheter-based near-infrared auto-fluorescence detection in human coronary plaques

Mie Kunio, Joseph A. Gardecki, Kohei Watanabe, Kensuke Nishimiya, Daisuke Yamada, Sarika Verma, Guillermo J. Tearney

研究成果: Conference contribution

抄録

There is significant histopathological and clinical evidence that near-infrared auto-fluorescence (NIRAF) complements optical coherence tomography (OCT) for detecting high-risk coronary plaque. Here, we determined the accuracy of an OCT-NIRAF imaging system and catheter for detecting NIRAF in human coronary lesions. OCT-NIRAF pullback imaging was performed on human cadaver coronary arteries (n=33 from 14 patients) during PBS perfusion via a fully integrated OCT-NIRAF imaging system and catheter (NIRAF ex. 633 nm, 1 mW power; em. 660-740nm). Confocal NIRAF images were acquired from corresponding unstained formalin-fixed paraffin-embedded sections (Olympus FLUOVIEW FV1000; ex. 635 nm; em. 655-755nm). OCT-NIRAF and confocal NIRAF images were registered using known pullback speed, anatomical landmarks, and fiducial features (e.g., calcification), and spatially overlapped by affine transformation of the confocal NIRAF images. Each image was split into 8, 45º-sectors, emanating from the catheter location. Each 45º-sector was determined to be positive if >5% of the intima contained confocal NIRAF, and if >5% of 45º-arc (2.25º) of the catheter-based NIRAF signal was above the system’s detection limit. A total of 1896 45º-sectors from 291 distinct coronary locations were analyzed using confocal NIRAF as the gold standard. Considering superficial confocal NIRAF foci within 0.5 mm from the luminal surface, sensitivity and specificity were 90.0% (95%CI: 69.8-100.0%) and 90.2% (95%CI: 88.8-91.7%), respectively. Within 0.5 mm to 1.0 mm depth from the luminal surface, the sensitivity was 36.4% (95%CI: 15.0-57.8%) and specificity was 90.1% (95%CI: 88.6-91.5%). These results indicate that the OCT-NIRAF system/catheter’s ability to detect NIRAF is depth dependent and accurate in plaque regions (within 0.5 mm from the luminal surface) that are most responsible for precipitating coronary events.

本文言語English
ホスト出版物のタイトルDiagnostic and Therapeutic Applications of Light in Cardiology 2021
編集者Laura Marcu, Gijs van Soest
出版社SPIE
ISBN(電子版)9781510640771
DOI
出版ステータスPublished - 2021
外部発表はい
イベントDiagnostic and Therapeutic Applications of Light in Cardiology 2021 - Virtual, Online, United States
継続期間: 2021 3 62021 3 11

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
11621
ISSN(印刷版)1605-7422

Conference

ConferenceDiagnostic and Therapeutic Applications of Light in Cardiology 2021
国/地域United States
CityVirtual, Online
Period21/3/621/3/11

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

フィンガープリント

「Accuracy of catheter-based near-infrared auto-fluorescence detection in human coronary plaques」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル