TY - GEN
T1 - Accuracy of catheter-based near-infrared auto-fluorescence detection in human coronary plaques
AU - Kunio, Mie
AU - Gardecki, Joseph A.
AU - Watanabe, Kohei
AU - Nishimiya, Kensuke
AU - Yamada, Daisuke
AU - Verma, Sarika
AU - Tearney, Guillermo J.
N1 - Funding Information:
This research was funded by Canon U.S.A., Inc., and the OCT-NIRAF imaging system and catheters were provided from Canon U.S.A., Inc. M.K., K.W., D.Y., and S.V. were/are employees of Canon U.S.A., Inc. during the conduct of this work. G.T. and J.A.G. are inventors on OCT-NIRAF technology patents. G.T. has a financial/fiduciary interest in SpectraWave, a company developing an OCT-NIRS intracoronary imaging system and catheter. His financial/fiduciary interest was reviewed and is managed by the Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. G.T. also has a consulting relationship with SpectraWave. G.T. receives sponsored research funding from Astrazeneca, VivoLight, CN USA Biotech Holdings, and Canon U.S.A., Inc.
Publisher Copyright:
© 2021 SPIE
PY - 2021
Y1 - 2021
N2 - There is significant histopathological and clinical evidence that near-infrared auto-fluorescence (NIRAF) complements optical coherence tomography (OCT) for detecting high-risk coronary plaque. Here, we determined the accuracy of an OCT-NIRAF imaging system and catheter for detecting NIRAF in human coronary lesions. OCT-NIRAF pullback imaging was performed on human cadaver coronary arteries (n=33 from 14 patients) during PBS perfusion via a fully integrated OCT-NIRAF imaging system and catheter (NIRAF ex. 633 nm, 1 mW power; em. 660-740nm). Confocal NIRAF images were acquired from corresponding unstained formalin-fixed paraffin-embedded sections (Olympus FLUOVIEW FV1000; ex. 635 nm; em. 655-755nm). OCT-NIRAF and confocal NIRAF images were registered using known pullback speed, anatomical landmarks, and fiducial features (e.g., calcification), and spatially overlapped by affine transformation of the confocal NIRAF images. Each image was split into 8, 45º-sectors, emanating from the catheter location. Each 45º-sector was determined to be positive if >5% of the intima contained confocal NIRAF, and if >5% of 45º-arc (2.25º) of the catheter-based NIRAF signal was above the system’s detection limit. A total of 1896 45º-sectors from 291 distinct coronary locations were analyzed using confocal NIRAF as the gold standard. Considering superficial confocal NIRAF foci within 0.5 mm from the luminal surface, sensitivity and specificity were 90.0% (95%CI: 69.8-100.0%) and 90.2% (95%CI: 88.8-91.7%), respectively. Within 0.5 mm to 1.0 mm depth from the luminal surface, the sensitivity was 36.4% (95%CI: 15.0-57.8%) and specificity was 90.1% (95%CI: 88.6-91.5%). These results indicate that the OCT-NIRAF system/catheter’s ability to detect NIRAF is depth dependent and accurate in plaque regions (within 0.5 mm from the luminal surface) that are most responsible for precipitating coronary events.
AB - There is significant histopathological and clinical evidence that near-infrared auto-fluorescence (NIRAF) complements optical coherence tomography (OCT) for detecting high-risk coronary plaque. Here, we determined the accuracy of an OCT-NIRAF imaging system and catheter for detecting NIRAF in human coronary lesions. OCT-NIRAF pullback imaging was performed on human cadaver coronary arteries (n=33 from 14 patients) during PBS perfusion via a fully integrated OCT-NIRAF imaging system and catheter (NIRAF ex. 633 nm, 1 mW power; em. 660-740nm). Confocal NIRAF images were acquired from corresponding unstained formalin-fixed paraffin-embedded sections (Olympus FLUOVIEW FV1000; ex. 635 nm; em. 655-755nm). OCT-NIRAF and confocal NIRAF images were registered using known pullback speed, anatomical landmarks, and fiducial features (e.g., calcification), and spatially overlapped by affine transformation of the confocal NIRAF images. Each image was split into 8, 45º-sectors, emanating from the catheter location. Each 45º-sector was determined to be positive if >5% of the intima contained confocal NIRAF, and if >5% of 45º-arc (2.25º) of the catheter-based NIRAF signal was above the system’s detection limit. A total of 1896 45º-sectors from 291 distinct coronary locations were analyzed using confocal NIRAF as the gold standard. Considering superficial confocal NIRAF foci within 0.5 mm from the luminal surface, sensitivity and specificity were 90.0% (95%CI: 69.8-100.0%) and 90.2% (95%CI: 88.8-91.7%), respectively. Within 0.5 mm to 1.0 mm depth from the luminal surface, the sensitivity was 36.4% (95%CI: 15.0-57.8%) and specificity was 90.1% (95%CI: 88.6-91.5%). These results indicate that the OCT-NIRAF system/catheter’s ability to detect NIRAF is depth dependent and accurate in plaque regions (within 0.5 mm from the luminal surface) that are most responsible for precipitating coronary events.
KW - Accuracy
KW - Coronary artery plaques
KW - Near-infrared autofluorescence
KW - Optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85108862900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108862900&partnerID=8YFLogxK
U2 - 10.1117/12.2582533
DO - 10.1117/12.2582533
M3 - Conference contribution
AN - SCOPUS:85108862900
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Diagnostic and Therapeutic Applications of Light in Cardiology 2021
A2 - Marcu, Laura
A2 - van Soest, Gijs
PB - SPIE
T2 - Diagnostic and Therapeutic Applications of Light in Cardiology 2021
Y2 - 6 March 2021 through 11 March 2021
ER -