Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits

Yoshiaki Sohma, Hironobu Sasano, Ryoko Shiga, Shigeru Saeki, Takashi Suzuki, Hiroshi Nagura, Masato Nose, Tokuo Yamamoto

研究成果: Article査読

36 被引用数 (Scopus)

抄録

By screening a cDNA library constructed from aortic total RNA derived ham Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the κ light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin γ heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.

本文言語English
ページ(範囲)4937-4941
ページ数5
ジャーナルProceedings of the National Academy of Sciences of the United States of America
92
11
DOI
出版ステータスPublished - 1995 5 23

ASJC Scopus subject areas

  • 一般

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