Accelerated memory decline in Alzheimer's disease with apolipoprotein ε4 allele

Nobutsugu Hirono, Mamoru Hashimoto, Minoru Yasuda, Hirokazu Kazui, Etsuro Mori

研究成果: Article査読

47 被引用数 (Scopus)

抄録

To investigate a possible effect of the apolipoprotein (APOE) ε4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE ε3/3, ε3/4, or ε4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall subtest, Word Recognition subtest, and total ADAS-Cog were significantly correlated with the number of APOE ε4 alleles after controlling for the effects of age, sex, education, test interval, and baseline scores. Findings revealed that APOE ε4 allele is related to an accelerated memory decline in AD.

本文言語English
ページ(範囲)354-358
ページ数5
ジャーナルJournal of Neuropsychiatry and Clinical Neurosciences
15
3
DOI
出版ステータスPublished - 2003 1月 1

ASJC Scopus subject areas

  • 臨床神経学
  • 精神医学および精神衛生

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