Absorption kinetics of ethanolamine plasmalogen and its hydrolysate in mice

Shinji Yamashita, Kazufumi Fujiwara, Yuki Tominaga, Ephantus Nguma, Takumi Takahashi, Yurika Otoki, Ayaka Yamamoto, Ohki Higuchi, Kiyotaka Nakagawa, Mikio Kinoshita, Teruo Miyazawa

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Ethanolamine plasmalogen (PlsEtn), a subclass of ethanolamine glycerophospholipid (EtnGpl), has been reported to have many biological and dietary functions. In terms of PlsEtn absorption, some studies have reported that PlsEtn is re-esterized at the sn-2 position using lymph cannulation and the everted jejunal sac model. In this study, we aimed to better understand the uptake kinetics of PlsEtn and increase its absorption. We thus compared the uptake kinetics of PlsEtn with that of the lyso-form, in which the fatty acid at the sn-2 position was hydrolyzed enzymatically. Upon administration of EtnGpl (extracted from oysters or ascidians, 75.4 mol% and 88.4 mol% of PlsEtn ratio, respectively), the plasma PlsEtn species in mice showed the highest levels at 4 or 8 hours after administration. In the contrast, administration of the EtnGpl hydrolysate, which contained lysoEtnGpl and free fatty acids, markedly increased the plasma levels of PlsEtn species at 2 h after administration. The area under the plasma concentration-time curve (AUC), especially the AUC0-4 h of PlsEtn species, was higher with hydrolysate administration than that with EtnGpl administration. These results indicate that EtnGpl hydrolysis accelerated the absorption and metabolism of PlsEtn. Consequently, using a different experimental approach from that used in previous studies, we reconfirmed that PlsEtn species were absorbed via hydrolysis at the sn-2 position, suggesting that hydrolysis in advance could increase PlsEtn uptake.

本文言語English
ページ(範囲)263-273
ページ数11
ジャーナルJournal of oleo science
70
2
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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