Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats

Watanabe Kamiyama Mari, Shimizu Muneshige, Kamiyama Shin, Taguchi Yasuki, Sone Hideyuki, Morimatsu Fumiki, Shirakawa Hitoshi, Furukawa Yuji, Komai Michio

研究成果: Article査読

99 被引用数 (Scopus)

抄録

Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [14C]proline (Pro group) or glycyl-[14C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolylhydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.

本文言語English
ページ(範囲)835-841
ページ数7
ジャーナルJournal of Agricultural and Food Chemistry
58
2
DOI
出版ステータスPublished - 2010 1 27

ASJC Scopus subject areas

  • 化学 (全般)
  • 農業および生物科学(全般)

フィンガープリント

「Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル