Absence of p51 mutation in human hepatocellular carcinoma

Kunihiro Hamada, Toru Koyama, Kimihiro Shimizu, Shuntaro Ikawa, Susumu Kawate, Jun Yokota, Susumu Ohwada, Yasuo Morishita

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.

本文言語English
ページ(範囲)161-164
ページ数4
ジャーナルCancer Letters
148
2
DOI
出版ステータスPublished - 2000 2 1
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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