Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.

A. K. Raina, X. Zhu, M. Monteiro, A. Takeda, M. A. Smith

研究成果: Review article査読

30 被引用数 (Scopus)

抄録

Alzheimer disease, the leading cause of senile dementia, is characterised by the degeneration of select neuronal populations. While the mechanism(s) underlying such cell loss are largely unknown, recent findings indicate inappropriate re-entry into the cell cycle resembling an abortive oncogeny. In postmitotic neurons, such mitotic re-entrance is deleterious and one that involves virtually the entire spectrum of the described pathological events in Alzheimer disease including, ultimately, cell death.

本文言語English
ページ(範囲)235-242
ページ数8
ジャーナルProgress in cell cycle research
4
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル