Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: Retrospective diagnosis by PCR using Guthrie cards

Kazuhiro Haginoya, Toshihiro Ohura, Kimiya Kon, Tsuneo Yagi, Yukio Sawaishi, Keiko Kumura Ishii, Tadao Funato, Shuichi Higano, Shoki Takahashi, Kazuie Iinuma

研究成果: Article査読

41 被引用数 (Scopus)

抄録

We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differential diagnosis of patients with abnormal white matter lesions and sensorineural hearing loss, one should consider congenital CMV infection. When investigating the etiology of patients with behavioral problems, migrational disorder, or white matter disease, PCR analysis of CMV DNA using blood stored on Guthrie cards might be helpful.

本文言語English
ページ(範囲)710-714
ページ数5
ジャーナルBrain and Development
24
7
DOI
出版ステータスPublished - 2002 10

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 発達神経科学
  • 臨床神経学

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