A versatile strategy for the synthesis of crown ether-bearing heterocycles: Discovery of calcium-selective fluoroionophore

Yuko Aoki, Naoki Umezawa, Yuko Asano, Keiichiro Hatano, Yuki Yano, Nobuki Kato, Tsunehiko Higuchi

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Heterocycles have been modified in various ways in the search for new functions, but few examples are known of crown ethers incorporating heterocycles in macro-ring systems. Here we report a simple and versatile synthesis of crown ether-bearing heterocycles. An acylurea moiety in the heterocycles is efficiently transformed to 'crown ether' of various ring sizes. The products included a Ca2+-selective fluoroionophore. Our simple methodology is expected to provide many novel functional heterocyclic compounds, including fluoroionophores and candidate pharmaceuticals.

本文言語English
ページ(範囲)7108-7115
ページ数8
ジャーナルBioorganic and Medicinal Chemistry
15
22
DOI
出版ステータスPublished - 2007 11 15

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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