A study by means of a new assay of the relationship between an outbreak of erythema infectiosum and non-immune hydrops fetalis caused by human parvovirus B19

Nobuo Yaegashi, Kunihiro Okamura, Akira Tsunoda, Masataka Nakamura, Kazuo Sugamura, Akira Yajima

研究成果: Article査読

6 被引用数 (Scopus)

抄録

An enzyme-linked immunosorbent assay (ELISA), used to detect IgG and IgM antibody specific for human parvovirus B19, was established by use of human parvovirus B19 capsid protein VP-1 Escherichia coli. Paired samples of serum derived from 44 mother and single samples derived from 24 babies having unexplained non-immune hydrops fetalis (NIHF), were tested by means of the assay. Five cases (11%) of NHIF were suspected of having been induced by intrauterine human parvovirus B19 infection because the samples of maternal serum were positive for parvorirus B19 IgM antibody. Four of the five cases arose during an outbreak of erythemia infectiosum. According to our study and previous reports over 90% of NIHF caused by parvovirus B19 intrauterine infection have become clinically overt in the second trimester of pregnancy during a period ranging from 15 to 27 weeks of gestation.

本文言語English
ページ(範囲)195-200
ページ数6
ジャーナルJournal of Infection
31
3
DOI
出版ステータスPublished - 1995 11

ASJC Scopus subject areas

  • 微生物学(医療)
  • 感染症

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