A simple proline-based organocatalyst for the enantioselective reduction of imines using trichlorosilane as a reductant

Takuya Kanemitsu, Atsushi Umehara, Rieko Haneji, Kazuhiro Nagata, Takashi Itoh

研究成果: Article査読

36 被引用数 (Scopus)

抄録

A simple and inexpensive proline-based organocatalyst was developed for the reduction of imines using trichlorosilane as a reductant. The reduction of N-aryl imines in the presence of 10 mol % of N-pivaloyl-l-proline anilide was carried out to give the corresponding amines in excellent yields (up to 99%) with high enantioselectivities (up to 93% ee).

本文言語English
ページ(範囲)3893-3898
ページ数6
ジャーナルTetrahedron
68
20
DOI
出版ステータスPublished - 2012 5月 20
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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