A simple and rapid method for high-resolution visualization of single-ion tracks

Masaaki Omichi, Wookjin Choi, Daisuke Sakamaki, Satoshi Tsukuda, Masaki Sugimoto, Shu Seki

研究成果: Article査読

抄録

Prompt determination of spatial points of single-ion tracks plays a key role in high-energy particle induced-cancer therapy and gene/plant mutations. In this study, a simple method for the high-resolution visualization of single-ion tracks without etching was developed through the use of polyacrylic acid (PAA)-N,N′-methylene bisacrylamide (MBAAm) blend films. One of the steps of the proposed method includes exposure of the irradiated films to water vapor for several minutes. Water vapor was found to promote the cross-linking reaction of PAA and MBAAm to form a bulky cross-linked structure; the ion-track scars were detectable at a nanometer scale by atomic force microscopy. This study demonstrated that each scar is easily distinguishable, and the amount of generated radicals of the ion tracks can be estimated by measuring the height of the scars, even in highly dense ion tracks. This method is suitable for the visualization of the penumbra region in a single-ion track with a high spatial resolution of 50 nm, which is sufficiently small to confirm that a single ion hits a cell nucleus with a size ranging between 5 and 20 μm.

本文言語English
論文番号117128
ジャーナルAIP Advances
4
11
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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