A synthesis system has been developed for routine preparation of the 11C-labeled receptor ligands, [11C]YM-09151-2 and [11C]pyrilamine, from [11C]methyl iodide produced automatically. The system features semi-automated operation, from the reaction of the desmethyl derivative with [11C]methyl iodide to filtration with a specifically developed syringe pump of the final product in saline into a sterile vial. The preparations were completed within 45 min after irradiation and approx. 1 GBq (27 mCi) of [11C]YM-09151-2 or [11C]pyrilamine was obtained with a radiochemical and chemical purity of >99% and an average specific activity of 44 GBq/μmol (1.2 Ci/μmol) at the end of synthesis. Sterile and pyrogen-free 11C-labeled receptor ligands suitable for human injection are routinely prepared using the present synthesis system.
|ジャーナル||International Journal of Radiation Applications and Instrumentation. Part|
|出版ステータス||Published - 1991|
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