抄録
Orally active converting enzyme inhibitor (Captopril, SQ 14225) was administered in a dose of 50 mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II) and 8 renovascular hypertensive patients (Group III). In Group III, 5 of 8 patients had control plasma renin activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of Captopril was greater in 7 of 8 patients than that in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renal aplasia. It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.
本文言語 | English |
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ページ(範囲) | 311-312 |
ページ数 | 2 |
ジャーナル | the tohoku journal of experimental medicine |
巻 | 131 |
号 | 3 |
DOI | |
出版ステータス | Published - 1980 |
ASJC Scopus subject areas
- 生化学、遺伝学、分子生物学(全般)