A realistic simulation of saccular cerebral aneurysm formation: Focussing on a novel haemodynamic index, the gradient oscillatory number

Y. Shimogonya, T. Ishikawa, Y. Imai, N. Matsuki, T. Yamaguchi

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Although how cerebral aneurysms initiate and grow is still unclear, haemodynamics is thought to play an important role. In order to better understand the aneurysm formation mechanism, we performed a computational analysis of aneurysm formation for a patient-specific arterial geometry. First, CFD was used to perform a pulsatile blood flow analysis and calculate a novel haemodynamic index, the gradient oscillatory number (GON). Then, using aneurysm growth model in which the proliferation of the wall was hypothesised, we performed an aneurysm formation analysis based on the GON index distribution. The result showed that a saccular cerebral aneurysm could appear based on our hypothesis for a patient-specific arterial geometry. On the other hand, a saccular aneurysm was not observed when assuming only strength degradation of the wall. Our findings have suggested that an arterial biological process, such as the proliferation of the wall, may play a vital role in saccular aneurysm formation.

本文言語English
ページ(範囲)583-593
ページ数11
ジャーナルInternational Journal of Computational Fluid Dynamics
23
8
DOI
出版ステータスPublished - 2009 9

ASJC Scopus subject areas

  • 計算力学
  • 航空宇宙工学
  • 凝縮系物理学
  • エネルギー工学および電力技術
  • 材料力学
  • 機械工学

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