A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada; Ren Iwata; Hiroshi Sugiyama; Kazunori Sato; Claudio Pascali; Hiroshi Fukuda; Kazuo Kubota; Roko Kubota; Hiromu Takahashi; Akira Wakui; Yoshinao Abe; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

doi:10.1002/jlcr.2580330706

A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada, Ren Iwata, Hiroshi Sugiyama, Kazunori Sato, Claudio Pascali, Hiroshi Fukuda, Kazuo Kubota, Roko Kubota, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

研究成果: Article

4 引用（Scopus）

抜粋

An efficient synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (Nω‐[¹⁸F]Fluoroacetyl‐5‐methoxytryptamine) starting from [¹⁸F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

元の言語	English
ページ（範囲）	601-606
ページ数	6
ジャーナル	Journal of Labelled Compounds and Radiopharmaceuticals
巻	33
発行部数	7
DOI	https://doi.org/10.1002/jlcr.2580330706
出版物ステータス	Published - 1993 7

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

文献にアクセス

10.1002/jlcr.2580330706

フィンガープリント A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606. https://doi.org/10.1002/jlcr.2580330706

A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. / Tada, Masao; Iwata, Ren; Sugiyama, Hiroshi; Sato, Kazunori; Pascali, Claudio; Fukuda, Hiroshi; Kubota, Kazuo; Kubota, Roko; Takahashi, Hiromu; Wakui, Akira; Abe, Yoshinao; Fujiwara, Takehiko; Sato, Tachio; Ido, Tatsuo.

：: Journal of Labelled Compounds and Radiopharmaceuticals, 巻 33, 番号 7, 07.1993, p. 601-606.

研究成果: Article

Tada, M, Iwata, R, Sugiyama, H, Sato, K, Pascali, C, Fukuda, H, Kubota, K, Kubota, R, Takahashi, H, Wakui, A, Abe, Y, Fujiwara, T, Sato, T & Ido, T 1993, 'A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent', Journal of Labelled Compounds and Radiopharmaceuticals, 巻. 33, 番号 7, pp. 601-606. https://doi.org/10.1002/jlcr.2580330706

Tada, Masao ; Iwata, Ren ; Sugiyama, Hiroshi ; Sato, Kazunori ; Pascali, Claudio ; Fukuda, Hiroshi ; Kubota, Kazuo ; Kubota, Roko ; Takahashi, Hiromu ; Wakui, Akira ; Abe, Yoshinao ; Fujiwara, Takehiko ; Sato, Tachio ; Ido, Tatsuo. / A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. ：: Journal of Labelled Compounds and Radiopharmaceuticals. 1993 ; 巻 33, 番号 7. pp. 601-606.

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abstract = "An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.",

keywords = "N‐[F]fluoroacetyl‐5‐methoxytryptamine, N‐fluoroacetyl‐5‐methoxytryptamine, [F]fluoride, [fluoroacetyl‐F]Fluoromelatonin, ethyl bromoacetate, ethyl p‐toluensulfonyloxyacetate",

author = "Masao Tada and Ren Iwata and Hiroshi Sugiyama and Kazunori Sato and Claudio Pascali and Hiroshi Fukuda and Kazuo Kubota and Roko Kubota and Hiromu Takahashi and Akira Wakui and Yoshinao Abe and Takehiko Fujiwara and Tachio Sato and Tatsuo Ido",

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T1 - A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

AU - Tada, Masao

AU - Iwata, Ren

AU - Sugiyama, Hiroshi

AU - Sato, Kazunori

AU - Pascali, Claudio

AU - Fukuda, Hiroshi

AU - Kubota, Kazuo

AU - Kubota, Roko

AU - Takahashi, Hiromu

AU - Wakui, Akira

AU - Abe, Yoshinao

AU - Fujiwara, Takehiko

AU - Sato, Tachio

AU - Ido, Tatsuo

PY - 1993/7

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AB - An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

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KW - N‐fluoroacetyl‐5‐methoxytryptamine

KW - [F]fluoride

KW - [fluoroacetyl‐F]Fluoromelatonin

KW - ethyl bromoacetate

KW - ethyl p‐toluensulfonyloxyacetate

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