A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada; Ren Iwata; Hiroshi Sugiyama; Kazunori Sato; Claudio Pascali; Hiroshi Fukuda; Kazuo Kubota; Roko Kubota; Hiromu Takahashi; Akira Wakui; Yoshinao Abe; Takehiko Fujiwara; Tachio Sato; Tatsuo Ido

doi:10.1002/jlcr.2580330706

A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada, Ren Iwata, Hiroshi Sugiyama, Kazunori Sato, Claudio Pascali, Hiroshi Fukuda, Kazuo Kubota, Roko Kubota, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

An efficient synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (Nω‐[¹⁸F]Fluoroacetyl‐5‐methoxytryptamine) starting from [¹⁸F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

本文言語	English
ページ（範囲）	601-606
ページ数	6
ジャーナル	Journal of Labelled Compounds and Radiopharmaceuticals
巻	33
号	7
DOI	https://doi.org/10.1002/jlcr.2580330706
出版ステータス	Published - 1993 7月

ASJC Scopus subject areas

分析化学
生化学
放射線学、核医学およびイメージング
創薬
分光学
有機化学

文献へのアクセス

10.1002/jlcr.2580330706

他のファイルとリンク

フィンガープリント

「A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606. https://doi.org/10.1002/jlcr.2580330706

Tada, M, Iwata, R, Sugiyama, H, Sato, K, Pascali, C, Fukuda, H, Kubota, K, Kubota, R, Takahashi, H, Wakui, A, Abe, Y, Fujiwara, T, Sato, T & Ido, T 1993, 'A rapid synthesis of [fluoroacetyl‐¹⁸F]fluoromelatonin (N^ω‐[¹⁸F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 33, no. 7, pp. 601-606. https://doi.org/10.1002/jlcr.2580330706

@article{c4df39a686714fadadbd5a92b1333519,

title = "A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent",

abstract = "An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.",

keywords = "N‐[F]fluoroacetyl‐5‐methoxytryptamine, N‐fluoroacetyl‐5‐methoxytryptamine, [F]fluoride, [fluoroacetyl‐F]Fluoromelatonin, ethyl bromoacetate, ethyl p‐toluensulfonyloxyacetate",

author = "Masao Tada and Ren Iwata and Hiroshi Sugiyama and Kazunori Sato and Claudio Pascali and Hiroshi Fukuda and Kazuo Kubota and Roko Kubota and Hiromu Takahashi and Akira Wakui and Yoshinao Abe and Takehiko Fujiwara and Tachio Sato and Tatsuo Ido",

year = "1993",

month = jul,

doi = "10.1002/jlcr.2580330706",

language = "English",

volume = "33",

pages = "601--606",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

AU - Tada, Masao

AU - Iwata, Ren

AU - Sugiyama, Hiroshi

AU - Sato, Kazunori

AU - Pascali, Claudio

AU - Fukuda, Hiroshi

AU - Kubota, Kazuo

AU - Kubota, Roko

AU - Takahashi, Hiromu

AU - Wakui, Akira

AU - Abe, Yoshinao

AU - Fujiwara, Takehiko

AU - Sato, Tachio

AU - Ido, Tatsuo

PY - 1993/7

Y1 - 1993/7

N2 - An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

AB - An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

KW - N‐[F]fluoroacetyl‐5‐methoxytryptamine

KW - N‐fluoroacetyl‐5‐methoxytryptamine

KW - [F]fluoride

KW - [fluoroacetyl‐F]Fluoromelatonin

KW - ethyl bromoacetate

KW - ethyl p‐toluensulfonyloxyacetate

UR - http://www.scopus.com/inward/record.url?scp=0027193933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027193933&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580330706

DO - 10.1002/jlcr.2580330706

M3 - Article

AN - SCOPUS:0027193933

VL - 33

SP - 601

EP - 606

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 7

ER -