A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent

Masao Tada, Ren Iwata, Hiroshi Sugiyama, Kazunori Sato, Claudio Pascali, Hiroshi Fukuda, Kazuo Kubota, Roko Kubota, Hiromu Takahashi, Akira Wakui, Yoshinao Abe, Takehiko Fujiwara, Tachio Sato, Tatsuo Ido

    研究成果: Article

    4 引用 (Scopus)


    An efficient synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]Fluoroacetyl‐5‐methoxytryptamine) starting from [18F]fluoride and ethyl p‐toluensulfonyloxyacetate is described. The total time required for its synthesis is ca. 90 min. The radiochemical yield, purity and specific activity (end of bombardment) of the desired compound are 14.2%,>98%, and 540 mCi/μmol, respectively.

    ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
    出版物ステータスPublished - 1993 7

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Biochemistry
    • Radiology Nuclear Medicine and imaging
    • Drug Discovery
    • Spectroscopy
    • Organic Chemistry

    フィンガープリント A rapid synthesis of [fluoroacetyl‐<sup>18</sup>F]fluoromelatonin (N<sup>ω</sup>‐[<sup>18</sup>F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Tada, M., Iwata, R., Sugiyama, H., Sato, K., Pascali, C., Fukuda, H., Kubota, K., Kubota, R., Takahashi, H., Wakui, A., Abe, Y., Fujiwara, T., Sato, T., & Ido, T. (1993). A rapid synthesis of [fluoroacetyl‐18F]fluoromelatonin (Nω‐[18F]fluoroacetyl‐5‐methoxytryptamine), a potential diagnostic imaging agent. Journal of Labelled Compounds and Radiopharmaceuticals, 33(7), 601-606. https://doi.org/10.1002/jlcr.2580330706