A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Kazuo Kubota; Takehiko Fujiwara; Hiroshi Sugiyama; Yoshinao Abe; Tachio Sato; Taiju Matsuzawa; Hiromu Takahashi; Akira Wakui; Tatsuo Ido

doi:10.1002/jlcr.2580280715

A rapid and efficient synthesis of 2‐deoxy‐2‐[¹⁸F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Kazuo Kubota, Takehiko Fujiwara, Hiroshi Sugiyama, Yoshinao Abe, Tachio Sato, Taiju Matsuzawa, Hiromu Takahashi, Akira Wakui, Tatsuo Ido

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

Rapid and efficient syntheses of 2‐deoxy‐2‐[¹⁸F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [¹⁸F]fluoride and ethyl bromoacetate are described. [¹⁸F]Fluoride was produced by the ¹⁸O (p, n) ¹⁸F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

本文言語	English
ページ（範囲）	847-854
ページ数	8
ジャーナル	Journal of Labelled Compounds and Radiopharmaceuticals
巻	28
号	7
DOI	https://doi.org/10.1002/jlcr.2580280715
出版ステータス	Published - 1990 1月 1

ASJC Scopus subject areas

分析化学
生化学
放射線学、核医学およびイメージング
創薬
分光学
有機化学

文献へのアクセス

10.1002/jlcr.2580280715

他のファイルとリンク

引用スタイル

Tada, M., Oikawa, A., Iwata, R., Sato, K., Kubota, K., Fujiwara, T., Sugiyama, H., Abe, Y., Sato, T., Matsuzawa, T., Takahashi, H., Wakui, A., & Ido, T. (1990). A rapid and efficient synthesis of 2‐deoxy‐2‐[¹⁸F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose. Journal of Labelled Compounds and Radiopharmaceuticals, 28(7), 847-854. https://doi.org/10.1002/jlcr.2580280715

Tada, M, Oikawa, A, Iwata, R, Sato, K, Kubota, K, Fujiwara, T, Sugiyama, H, Abe, Y, Sato, T, Matsuzawa, T, Takahashi, H, Wakui, A & Ido, T 1990, 'A rapid and efficient synthesis of 2‐deoxy‐2‐[¹⁸F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 28, no. 7, pp. 847-854. https://doi.org/10.1002/jlcr.2580280715

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abstract = "Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.",

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T1 - A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

AU - Tada, Masao

AU - Oikawa, Atsushi

AU - Iwata, Ren

AU - Sato, Kazunori

AU - Kubota, Kazuo

AU - Fujiwara, Takehiko

AU - Sugiyama, Hiroshi

AU - Abe, Yoshinao

AU - Sato, Tachio

AU - Matsuzawa, Taiju

AU - Takahashi, Hiromu

AU - Wakui, Akira

AU - Ido, Tatsuo

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AB - Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

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