A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose

Masao Tada, Atsushi Oikawa, Ren Iwata, Kazunori Sato, Kazuo Kubota, Takehiko Fujiwara, Hiroshi Sugiyama, Yoshinao Abe, Tachio Sato, Taiju Matsuzawa, Hiromu Takahashi, Akira Wakui, Tatsuo Ido

    研究成果: Article査読

    4 被引用数 (Scopus)

    抄録

    Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.

    本文言語English
    ページ(範囲)847-854
    ページ数8
    ジャーナルJournal of Labelled Compounds and Radiopharmaceuticals
    28
    7
    DOI
    出版ステータスPublished - 1990 1月 1

    ASJC Scopus subject areas

    • 分析化学
    • 生化学
    • 放射線学、核医学およびイメージング
    • 創薬
    • 分光学
    • 有機化学

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