A practical synthesis of a hydroxylated sesquiterpene coumarin 10′R-acetoxy-11′-hydroxyumbelliprenin by regioselective dihydroxylation

Yasunao Hattori, Genki Kinami, Kenta Teruya, Kazuto Nosaka, Kazuya Kobayashi, Kenichi Akaji

研究成果: Article査読

抄録

A practical synthesis of 10′R-acetoxy-11′-hydroxyumbelliprenin was achieved using regioselective Sharpless asymmetric dihydroxylation as a key reaction, in which the regioselectivity was achieved by using (DHQD) 2AQN as a ligand instead of the conventional (DHQD)2PHAL. 10′R-Acetoxy-11′-hydroxyumbelliprenin was synthesized by the coupling of a coumarin unit (umbelliferone) and sesquiterpene unit in 11% overall yield through 5 steps.

本文言語English
ページ(範囲)423-428
ページ数6
ジャーナルHeterocycles
87
2
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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