A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl 4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

Savita Bisht, Mehtab A. Khan, Mena Bekhit, Haibo Bai, Toby Cornish, Masamichi Mizuma, Michelle A. Rudek, Ming Zhao, Amarnath Maitra, Balmiki Ray, Debomoy Lahiri, Anirban Maitra, Robert A. Anders

研究成果: Article査読

78 被引用数 (Scopus)

抄録

Plant-derived polyphenols such as curcumin hold promise as a therapeutic agent in the treatment of chronic liver diseases. However, its development is plagued by poor aqueous solubility resulting in poor bioavailability. To circumvent the suboptimal bioavailability of free curcumin, we have developed a polymeric nanoparticle formulation of curcumin (NanoCurc) that overcomes this major pitfall of the free compound. In this study, we show that NanoCurc results in sustained intrahepatic curcumin levels that can be found in both hepatocytes and non-parenchymal cells. NanoCurc markedly inhibits carbon tetrachloride-induced liver injury, production of pro-inflammatory cytokines and fibrosis. It also enhances antioxidant levels in the liver and inhibits pro-fibrogenic transcripts associated with activated myofibroblasts. Finally, we show that NanoCurc directly induces stellate cell apoptosis in vitro. Our results suggest that NanoCurc might be an effective therapy for patients with chronic liver disease.

本文言語English
ページ(範囲)1383-1395
ページ数13
ジャーナルLaboratory Investigation
91
9
DOI
出版ステータスPublished - 2011 9
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 分子生物学
  • 細胞生物学

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