A platform for controlled dual-drug elivery to the retina: Protective effects against light-Induced retinal damage in rats

Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.

本文言語English
ページ(範囲)1555-1560
ページ数6
ジャーナルAdvanced Healthcare Materials
3
10
DOI
出版ステータスPublished - 2014 10 1

ASJC Scopus subject areas

  • 生体材料
  • 生体医工学
  • 薬科学

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