A novel transformation of primary amines to N-monoalkylhydroxylamines

H. Tokuyama, T. Kuboyama, A. Amano, T. Yamashita, T. Fukuyama

研究成果: Article

49 引用 (Scopus)

抜粋

A novel transformation of primary amines to the corresponding N-monoalkylhydroxylamines is described. The three-step protocol involves selective mono-cyanomethylation of primary amines, regioselective formation of nitrones by m-CPBA oxidation, and hydroxylaminolysis of the nitrones with hydroxylamine hydrochloride. The method is applicable for a wide range of primary amines, including alkyl, benzyl, and chiral.

元の言語English
ページ(範囲)1299-1304
ページ数6
ジャーナルSynthesis
発行部数9
出版物ステータスPublished - 2000 9 2
外部発表Yes

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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  • これを引用

    Tokuyama, H., Kuboyama, T., Amano, A., Yamashita, T., & Fukuyama, T. (2000). A novel transformation of primary amines to N-monoalkylhydroxylamines. Synthesis, (9), 1299-1304.