A novel recognition system for MHC class I molecules constituted by PIR

研究成果: Review article査読

41 被引用数 (Scopus)

抄録

The paired immunoglobulin (Ig)-like receptors (PIRs) represent a typical receptor pair of the Ig-like receptor family in which various combinations of ligand-receptor interaction provide a positive and negative regulation of immune cells, thus enabling those cells to respond properly to extrinsic stimuli. Activating PIR-A and inhibitory PIR-B are expressed in a wide range of cells in the murine immune system, such as B cells, mast cells, macrophages, and dendritic cells, mostly in a pair-wise fashion. PIRs bind to MHC class I molecules expressed ubiquitously on hematopoietic as well as nonhematopoietic cells. The unbalanced binding of PIR-A and PIR-B to MHC class I molecules may lead to the perturbation of cell development, regulation, and function as observed in PIR-B-deficient mice. Thus, PIR-A and PIR-B are indispensable for the regulation of cellular signaling and important for homeostasis of the immune system.

本文言語English
ページ(範囲)161-192
ページ数32
ジャーナルAdvances in Immunology
88
DOI
出版ステータスPublished - 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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