TY - JOUR
T1 - A novel protocol for construction of indolylmethyl group at aldehydes or ketones
AU - Tokuyama, H.
AU - Watanabe, M.
AU - Hayashi, Y.
AU - Kurokawa, T.
AU - Peng, G.
AU - Fukuyama, T.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - A new method for introduction of indolylmethyl group to aldehydes or ketones using diethyl (o-isocyanophenylmethyl) phosphonate through Horner-Wadsworth-Emmons condensation, thiolmediated radical cyclization, and the subsequent desulfurization is described. The Horner-Wadsworth-Emmons reagent was prepared from 2-nitrobenzaldehyde in a concise three-step sequence.
AB - A new method for introduction of indolylmethyl group to aldehydes or ketones using diethyl (o-isocyanophenylmethyl) phosphonate through Horner-Wadsworth-Emmons condensation, thiolmediated radical cyclization, and the subsequent desulfurization is described. The Horner-Wadsworth-Emmons reagent was prepared from 2-nitrobenzaldehyde in a concise three-step sequence.
KW - 2-Alkenylphenyl isocyanides
KW - 3-Substituted indoles
KW - Diethyl (o-isocyanophenylmethyl) phosphonate
KW - Horner-Wadsworth-Emmons condensation
KW - Thiol-mediated radical cyclization
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U2 - 10.1055/s-2001-16808
DO - 10.1055/s-2001-16808
M3 - Article
AN - SCOPUS:0034847193
SN - 0936-5214
SP - 1403
EP - 1406
JO - Synlett
JF - Synlett
IS - 9
ER -