A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes

Hisashi Okimoto, Yasushi Ishigaki, Yoshihiro Koiwa, Yoshinori Hinokio, Takehide Ogihara, Susumu Suzuki, Hideki Katagiri, Takayoshi Ohkubo, Hideyuki Hasegawa, Hiroshi Kanai, Yoshitomo Oka

研究成果: Article査読

35 被引用数 (Scopus)

抄録

We recently developed a novel method for evaluating the elasticity of arterial walls, the phased tracking method. Herein, we evaluated atherosclerosis of the carotid artery with this method in 242 individuals with type 2 diabetes. In multiple regression analysis of subject status, age, systolic blood pressure and hyperlipidemia were found to be independently associated with carotid artery elasticity values. We also measured currently established values for atherosclerosis, carotid artery IMT and baPWV, in these subjects. Carotid artery elasticity correlated with max IMT (r = 0.291, p < 0.01), plaque score (PS) (r = 0.220, p < 0.01) and baPWV (r = 0.345, p < 0.01). Elasticity, max IMT and plaque score, all correlated with the number of risk factors for atherosclerosis, i.e. hypertension, hyperlipidemia and smoking, in addition to diabetes, consistent with the view that these values reflect atherosclerosis. Importantly, however, in subjects with IMT <1.1 mm, who are classified as not having atherosclerosis as defined by IMT criteria, only carotid artery elasticity correlated with the number of risk factors (p < 0.05). These results suggest that (1) the measured carotid artery elasticity values reflect atherosclerosis and (2) our novel method has potential for detecting atherosclerosis in its early stage.

本文言語English
ページ(範囲)391-397
ページ数7
ジャーナルAtherosclerosis
196
1
DOI
出版ステータスPublished - 2008 1

ASJC Scopus subject areas

  • 循環器および心血管医学

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