A novel mechanism of depression: role for connexins

Cong Yuan Xia, Zhen Zhen Wang, Tohru Yamakuni, Nai Hong Chen

研究成果: Review article査読

14 被引用数 (Scopus)

抄録

Major depressive disorder (MDD) is a chronic and debilitating illness that affects over 350 million people worldwide; however, current treatments have failed to cure or prevent the progress of depression. Increasing evidence suggests a crucial role for connexins in MDD. In this review, we have summarised recent accomplishments regarding the role of connexins, gap junctions, and hemichannels in the aetiology of MDD, and discussed the limitations of current research. A blockage of gap junctions or hemichannels induces depressive behaviour. Possible underlying mechanisms include the regulation of neurosecretory functions and synaptic activity by gap junctions and hemichannels. Gap junctions are functionally inhibited under stress conditions. Conversely, hemichannel permeability is increased. Antidepressants inhibit hemichannel permeability; however, they have contrasting effects on the function of gap junctions under normal conditions and can protect them against stress. In conclusion, the blockage of hemichannels concurrent with improvements in gap junction functionality might be potential targets for depression treatment.

本文言語English
ページ(範囲)483-498
ページ数16
ジャーナルEuropean Neuropsychopharmacology
28
4
DOI
出版ステータスPublished - 2018 4

ASJC Scopus subject areas

  • 薬理学
  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学
  • 薬理学(医学)

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