A novel gene ″Niban″ upregulated in renal carcinogenesis: Cloning by the cDNA-amplified fragment length polymorphism approach

Shuichi Majima, Kazunori Kajino, Tomokazu Fukuda, Fujio Otsuka, Okio Hino

研究成果: Article

33 引用 (Scopus)

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A modified AFLP (amplified fragment length polymorphism) method was employed to isolate genes differentially expressed in renal carcinogenesis of Tsc2 gene mutant (Eker) rats. One gene, selected for further investigation, was named ″Niban″ (″second″ in Japanese), because it is the second new gene to be found after Erc (expressed in renal carcinoma) in our laboratory. Importantly, ″Niban″ is well expressed even in small primary rat Eker renal tumors, more than in progressed cell lines, and is also expressed in human renal carcinoma cells, but not in normal human or rat kidneys. Chromosome assignment was to RNO 13 in the rat, and HSA 1. This ″Niban″ gene is a candidate as a marker for renal tumor, especially early-stage renal carcinogenesis.

元の言語English
ページ(範囲)869-874
ページ数6
ジャーナルJapanese Journal of Cancer Research
91
発行部数9
DOI
出版物ステータスPublished - 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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