TY - JOUR
T1 - A novel device for left atrial appendage exclusion
AU - Kamohara, Keiji
AU - Fukamachi, Kiyotaka
AU - Ootaki, Yoshio
AU - Akiyama, Masatoshi
AU - Zahr, Firas
AU - Kopcak, Michael W.
AU - Dessoffy, Raymond
AU - Popović, Zoran B.
AU - Daimon, Masao
AU - Cosgrove, Delos M.
AU - Marc Gillinov, A.
N1 - Funding Information:
Supported by AtriCure, Inc (Cincinnati, Ohio).
PY - 2005/12
Y1 - 2005/12
N2 - Objective: The left atrial appendage is a frequent source of thromboemboli in patients with atrial fibrillation. Exclusion or excision of the left atrial appendage may reduce the risk of stroke in patients with atrial fibrillation. We evaluated the ability of a novel device to exclude the left atrial appendage during early and intermediate follow-up periods in a canine model. Methods: Eight mongrel dogs (mean weight 29.1 ± 4.0 kg) were used in this study. The occlusion device, constructed from 2 stainless steel strips covered with a knit braided polyester fabric, was implanted at the base of the left atrial appendage through a left thoracotomy on a beating heart. Dogs were evaluated at 7 days (n = 2), 30 days (n = 2), and 90 days (n = 4) by epicardial echocardiography, left atrial angiography, histologic inspection, and gross pathology. Results: Device implantation was performed without complications in all animals. Complete exclusion of the left atrial appendage from the circulation was confirmed acutely and chronically by echocardiographic and angiographic evaluations. There was no device migration or damage to adjacent structures. Conclusion: This novel device enables rapid, reliable, and safe exclusion of the left atrial appendage. The device provides a new therapeutic option for reducing the risk of stroke in patients with atrial fibrillation.
AB - Objective: The left atrial appendage is a frequent source of thromboemboli in patients with atrial fibrillation. Exclusion or excision of the left atrial appendage may reduce the risk of stroke in patients with atrial fibrillation. We evaluated the ability of a novel device to exclude the left atrial appendage during early and intermediate follow-up periods in a canine model. Methods: Eight mongrel dogs (mean weight 29.1 ± 4.0 kg) were used in this study. The occlusion device, constructed from 2 stainless steel strips covered with a knit braided polyester fabric, was implanted at the base of the left atrial appendage through a left thoracotomy on a beating heart. Dogs were evaluated at 7 days (n = 2), 30 days (n = 2), and 90 days (n = 4) by epicardial echocardiography, left atrial angiography, histologic inspection, and gross pathology. Results: Device implantation was performed without complications in all animals. Complete exclusion of the left atrial appendage from the circulation was confirmed acutely and chronically by echocardiographic and angiographic evaluations. There was no device migration or damage to adjacent structures. Conclusion: This novel device enables rapid, reliable, and safe exclusion of the left atrial appendage. The device provides a new therapeutic option for reducing the risk of stroke in patients with atrial fibrillation.
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U2 - 10.1016/j.jtcvs.2005.08.019
DO - 10.1016/j.jtcvs.2005.08.019
M3 - Article
C2 - 16308010
AN - SCOPUS:27944432960
VL - 130
SP - 1639
EP - 1644
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 6
ER -