A novel covalently crosslinked gel of alginate and silane with the ability to form bone-like apatite

Kayo Hosoya, Chikara Ohtsuki, Takahiro Kawai, Masanobu Kamitakahara, Shin Ichi Ogata, Toshiki Miyazaki, Masao Tanihara

研究成果: Article査読

55 被引用数 (Scopus)

抄録

Hybrids consisting of bone-like apatite and biodegradable polymers are attractive materials for bone repair. We have shown that an alginate gel crosslinked covalently with ethylenediamine (EDA) enhances the repair of skin and nerves. In this study, we report a novel method for fabrication of an apatite-alginate nanohybrid using a simulated body fluid (SBF). Alginate was reacted with 3-aminopropyltriethoxysilane (APES), which gives silanol groups after hydrolysis, and/or EDA, by dehydration condensation using water-soluble carbodiimide to form gels. Modification of alginate with APES alone also gave a gel, because the alginate could be crosslinked by dehydration of silanol groups derived from APES. The gels obtained were soaked in a 1 mol/L CaCl2 solution and subsequently soaked in SBF. Apatite was formed on and inside the alginate gels modified with APES, whereas it was not formed on the gels without APES. Modification of alginate with silanol groups induced not only gel formation but also the apatite-forming ability on and inside the alginate gel in SBF. Consequently, a hydroxyapatite-alginate hybrid can be produced by modification of alginate with silanol groups and subsequent soaking in CaCl 2 solution and SBF. Such a material is expected to be useful in bone repair.

本文言語English
ページ(範囲)596-601
ページ数6
ジャーナルJournal of Biomedical Materials Research - Part A
71
4
DOI
出版ステータスPublished - 2004 12 15
外部発表はい

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

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