A novel chiral oxazolidine organocatalyst for the synthesis of an oseltamivir intermediate using a highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine

Hiroto Nakano, Kenichi Osone, Mitsuhiro Takeshita, Eunsang Kwon, Chigusa Seki, Haruo Matsuyama, Nobuhiro Takano, Yoshihito Kohari

研究成果: Article査読

91 被引用数 (Scopus)

抄録

Enantioselective Diels-Alder reactions of 1,2-dihydropyridines with acroleins using a novel chiral oxazolidine organocatalyst afforded chiral isoquinuclidines that is an efficient synthetic intermediate of oseltamivir, with fairly good chemical yield and excellent enantioselectivity (90%, up to >99% ee).

本文言語English
ページ(範囲)4827-4829
ページ数3
ジャーナルChemical Communications
46
26
DOI
出版ステータスPublished - 2010 7 14

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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