A new type of amino amide organocatalyzed enantioselective crossed aldol reaction of ketones with aromatic aldehydes

Isiaka A. Owolabi, U. V. Subba Reddy, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

A new type of amino amide organocatalysts was designed and synthesized from commercially available amino acids in easy steps. Their catalytic activities were examined in enantioselective crossed aldol reaction of various acyclic and cyclic ketones with aromatic aldehydes to afford the corresponding chiral anti-aldol adducts with good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to syn:anti = 1:99, up to 97% ee).

本文言語English
ページ(範囲)4705-4711
ページ数7
ジャーナルTetrahedron
74
36
DOI
出版ステータスPublished - 2018 9 6

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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