A new taxane composed of two N-formyl rotamers from Taxus canadensis

Man Li Zhang, Mei Dong, Xiao Ning Li, Li Geng Li, Fançoise Sauriol, Chang Hong Huo, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota, Bin Cong

研究成果: Article査読

8 被引用数 (Scopus)

抄録

A taxane with an amino-side chain on C-5 was identified for the first time from rooted cuttings of the Canadian yew, Taxus canadensis. The structure was characterized as 7β,9α,10β,13α-tetraacetoxy-5α-[3′-(N-formyl-N-methylamino)-3′-phenylpropanoyl]oxytaxa-4(20),12-diene (1) on the basis of 1D-, 2D-NMR data, and HR-FABMS analyses. The spectra revealed that in CDCl3 solution 1 was composed of two rotamers (1a and 1b) in a ratio of approximately 2:1.

本文言語English
ページ(範囲)3405-3408
ページ数4
ジャーナルTetrahedron Letters
49
21
DOI
出版ステータスPublished - 2008 5 19

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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