A new stiffness evaluation toward high speed cell sorter

Yuki Hirose, Kenjiro Tadakuma, Mitsuru Higashimori, Tatsuo Arai, Makoto Kaneko, Ryo Iitsuka, Yoko Yamanishi, Fumihito Arai

研究成果: Conference contribution

40 被引用数 (Scopus)

抄録

Cell stiffness could be an index for evaluating its activity. Although various systems measuring cell stiffness have been proposed so far, they are slow for adaptively connecting to cell sorters capable of handling more than 1000 [cells/sec]. This paper proposes a new approach that can indirectly evaluate the cell stiffness by measuring the passing time for a narrow channel. When a cell passes through the channel, it receives a viscous force depending upon how much deformation is exerted on the cell. We show that the stiffness is a function of both the passing time and the initial diameter of cell. We also show that the stiffness is proportional to the passing time and inversely proportional to the initial diameter, under the assumption that the thickness of fluid film is inversely proportional to the normal force. The experimental validation is given together with the basic working principle.

本文言語English
ホスト出版物のタイトル2010 IEEE International Conference on Robotics and Automation, ICRA 2010
ページ4113-4118
ページ数6
DOI
出版ステータスPublished - 2010 8 26
外部発表はい
イベント2010 IEEE International Conference on Robotics and Automation, ICRA 2010 - Anchorage, AK, United States
継続期間: 2010 5 32010 5 7

出版物シリーズ

名前Proceedings - IEEE International Conference on Robotics and Automation
ISSN(印刷版)1050-4729

Other

Other2010 IEEE International Conference on Robotics and Automation, ICRA 2010
国/地域United States
CityAnchorage, AK
Period10/5/310/5/7

ASJC Scopus subject areas

  • ソフトウェア
  • 制御およびシステム工学
  • 人工知能
  • 電子工学および電気工学

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