A new lead chemical for strigolactone biosynthesis inhibitors

Shinsaku Ito, Nobutaka Kitahata, Mikihisa Umehara, Atsushi Hanada, Atsutaka Kato, Kotomi Ueno, Kiyoshi Mashiguchi, Junko Kyozuka, Koichi Yoneyama, Shinjiro Yamaguchi, Tadao Asami

    研究成果: Article査読

    34 被引用数 (Scopus)

    抄録

    Several triazole-containing chemicals have previously been shown to act as efficient inhibitors of cytochrome P450 monooxygenases. To discover a strigolactone biosynthesis inhibitor, we screened a chemical library of triazole derivatives to find chemicals that induce tiller bud outgrowth of rice seedlings. We discovered a triazole-type chemical, TIS13 [2,2-dimethyl-7- phenoxy-4-(1H-1,2,4-triazol-1-yl)heptan-3-ol], which induced outgrowth of second tiller buds of wild-type seedlings, as observed for non-treated strigolactone-deficient d10 mutant seedlings. TIS13 treatment reduced strigolactone levels in both roots and root exudates in a concentration- dependent manner. Co-application of GR24, a synthetic strigolactone, with TIS13 canceled the TIS13-induced tiller bud outgrowth. Taken together, these results indicate that TIS13 inhibits strigolactone biosynthesis in rice seedlings. We propose that TIS13 is a new lead compound for the development of specific strigolactone biosynthesis inhibitors.

    本文言語English
    ページ(範囲)1143-1150
    ページ数8
    ジャーナルPlant and Cell Physiology
    51
    7
    DOI
    出版ステータスPublished - 2010 7月

    ASJC Scopus subject areas

    • 生理学
    • 植物科学
    • 細胞生物学

    フィンガープリント

    「A new lead chemical for strigolactone biosynthesis inhibitors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル