A model for ocular dominance plasticity controlled by feedforward and feedback inhibition

Ichiro Sakurai, Shigeru Kubota, Michio Niwano

研究成果: Article査読

抄録

The maturation of inhibitory transmission through γ- aminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effects of such local pathways associated with cortical inhibition on the induction of OD plasticity, we compared synaptic modification dynamics regulated by feedforward inhibition and those regulated by feedback inhibition. Feedforward inhibition facilitated competitive interactions between different groups of inputs conveying correlated activities, which were required for the emergence of experience-dependent plasticity. Conversely, feedback inhibition suppressed competitive interactions and prevented synapses from reflecting past sensory experience. Our results suggest that the balance between feedforward and feedback inhibition regulates the timing and level of cortical plasticity by modulating competition among synapses. This result suggests an importance of activity-dependent competition in experience-dependent OD plasticity, which is in line with the results of previous experiments.

本文言語English
ページ(範囲)1780-1786
ページ数7
ジャーナルIEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences
E97-A
8
DOI
出版ステータスPublished - 2014 8

ASJC Scopus subject areas

  • 信号処理
  • コンピュータ グラフィックスおよびコンピュータ支援設計
  • 電子工学および電気工学
  • 応用数学

フィンガープリント

「A model for ocular dominance plasticity controlled by feedforward and feedback inhibition」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル