A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc

Tetsuji Kubo, Chiharu Katoh, Ken Yamada, Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama

研究成果: Article査読

84 被引用数 (Scopus)

抄録

A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.

本文言語English
ページ(範囲)11230-11236
ページ数7
ジャーナルTetrahedron
64
49
DOI
出版ステータスPublished - 2008 12 1

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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