A horseshoe crab receptor structurally related to Drosophila Toll

K. I. Inamori, K. Koori, C. Mishima, T. Muta, S. I. Kawabata

研究成果: Article査読

14 被引用数 (Scopus)


Innate immunity against microbial pathogens relies on the pattern recognition of cell wall components on invading microbes. Recent evidence has shown that a mammalian Toll-like receptor (TLR) is activated by bacterial lipopolysaccharides (LPS). The innate immunity in invertebrates is also triggered by LPS, as seen in the hemolymph coagulation in horseshoe crab. We report the cloning of a TLR from the Japanese horseshoe crab Tachypleus tridentatus. A cDNA coding for Tachypleus Toll was isolated from a hemocyte cDNA library and the open reading frame codes for a proprotein including a signal sequence. Like Drosophila Toll, Tachypleus Toll is a type I transmembrane protein with an extracellular domain consisting of two leucine-rich repeats flanked by two cystein-rich clusters and a cytoplasmic domain exhibiting striking similarity with the cytoplasmic domain of interleukin-1 receptor. Tachypleus Toll is most similar to Drosophila Toll in the domain architecture and the overall length.

ジャーナルJournal of Endotoxin Research
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 微生物学
  • 免疫学
  • 分子生物学
  • 細胞生物学
  • 感染症


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