A histopathological study of lymphoepithelial island formation in labial salivary glands in patients with primary Sjogren's syndrome

Yukiko Yamamura, Ken Onodera, Ryo Ichinohasama, Kiyoshi Ooya

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The proliferative status of lymphoepithelial islands in the labial salivary glands of primary Sjogren's syndrome (pSS) patients was investigated by counting the number of argyrophilic nucleolar organizer regions (AgNORs) in epithelial cells constituting the islands. The islands were classified into four groups and evaluated in terms of total area and three discrete zones of the islands. In each pSS group, the mean AgNOR number per total island epithelial cell nucleus was significantly higher than in control ductal epithelial cells. The zonal AgNOR number fluctuated during the process of island formation but became more uniform as the islands developed. Furthermore, statistically significant trends among the four pSS groups were observed in the ratio of T lymphocytes, B lymphocytes and plasma cells surrounding the islands. The results indicated that the islands are highly proliferative once island formation begins and that zonal island cell proliferation may be associated with the inflammatory cells.

本文言語English
ページ(範囲)110-117
ページ数8
ジャーナルJournal of Oral Pathology and Medicine
29
3
DOI
出版ステータスPublished - 2000 3

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

フィンガープリント 「A histopathological study of lymphoepithelial island formation in labial salivary glands in patients with primary Sjogren's syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル