A highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine using a simple β-amino alcohol organocatalyst for a practical synthetic methodology of oseltamivir intermediate

Chonticha Suttibut, Yoshihito Kohari, Ko Igarashi, Hiroto Nakano, Masafumi Hirama, Chigusa Seki, Haruo Matsuyama, Koji Uwai, Nobuhiro Takano, Yuko Okuyama, Kenichi Osone, Mitsuhiro Takeshita, Eunsang Kwon

研究成果: Article査読

35 被引用数 (Scopus)

抄録

An easily prepared chiral amino alcohol catalyst was found to provide an efficient synthetic intermediate of oseltamivir with excellent chemical yield and enantioselectivity (up to 98% yield and up to 98% ee) in enantioselective Diels-Alder reactions of 1,2-dihydropylidines with acroleins.

本文言語English
ページ(範囲)4745-4748
ページ数4
ジャーナルTetrahedron Letters
52
37
DOI
出版ステータスPublished - 2011 9 14

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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